Hmmm...
Today, as you might have heard, is the 30th anniversary of the Game Boy. Since I'm going to be using PICO-8 or TIC-80 anyway, perhaps I could try making my game in a monochrome 4-colour palette? It'd be an extra challenge, and a celebration of the Game Boy's birthday - the first console I ever owned was a Game Boy Color, so I'd like to do something to honour it.
I guess I'll decide once I see what the theme is and settle on my game idea. But for now, it's an interesting thought.