I've settled on something that I'm almost happy with, so if you're out there struggling to think of anything, here are my unused concepts:

• You're a stock broker with insane medical bills, and you're just trying to keep up. Do you forgo a time-sensitive surgery and invest that money is a lucrative stock? Selling organs?
• Managing multiple characters that you can buy and sell. A tycoon game with a turbocapitalist mentality. Play into the criticisms of capitalism, that it puts a number value on a human life.
• "Your life" meaning "your social life"
• Navigating a society of vampires that will trade stuff for your blood
• You're a monster that must eat money to survive
• Throwing chunks of your bodies at enemies (?)

Good luck, y'all.