I can think of a ton of ideas, but trying to think of one that I can do in 48 hrs that is going to stand out is where the challenge always lies, I also still have work to do this weekend, so who knows

I've got one absolutely killer idea that I cannot do on my own, would probably take a decently sizeable team (if you want it, you can have it, I will play it if you do): It is a drone-based organ transplant delivery service, working title could be D (for drone)-Liver-y. The only problem is that the only way for the drone to carry the organs is with a claw machine claw. It would be an I am Bread/I am Fish-style rage game that combines soft-body physics of organs with flight controls of a drone with the infuriating claw mechanics of a claw machine.