It’s dangerous to go alone, take a friend with you
So while this was the theme I knew I could never get a proper idea for, I went with this one:
A friendship roguelike.
Your character suffers from extreme loneliness, to the point where it’s actually unhealthy.
Point of the game is to go out and gain friends, and befriend them enough so that they’ll give you kind words, items or phone-numbers at the point where it gets late and they have to leave you, and you’ll be struggling with your loneliness in your apartment.
It’s a survival game where you’ll try to survive each day and struggle with your autophobia