Help needed: "ALCHEMY unSTABLE" - good idea to make serious game?

Hello!

We've made ALCHEMY unSTABLE game for the last LD. We had fun making, people had fun playing and a feedback is mostly positive. So we start thinking about making something serious out of it. BUT! We have a problem with progression and more long-lasting gameplay development.

https://www.youtube.com/watch?v=uQgXwHnktYU

If one came up with general idea of how to solve puzzles in this game, the gameplay becomes tedious and boring.

So here I am summoning a LD community collective mind to ask a couple of questions:

  1. How to create long term gameplay development? Any ideas for meta gameplay?
  2. Any ideas with the core gameplay? Controls change?
  3. Is it a good idea to create a serious game out of this concept?

Game link
https://ldjam.com/events/ludum-dare/49/alchemy-unstable