I'm off the mark
After a lot of brainstorming, I've settled on doing a Metroidvania-type game. The concept is simple: your wife is dying of a rare disease, and you must venture into a dangerous temple to retrieve a rare flower that won't cure her, but will at least delay the inevitable, and give you more time with her before she passes on. I'm gonna try and do two endings: a good ending where you return with the flower in time, and a bad ending where you don't.
I'm treating it as a spiritual successor to my LD43 entry, The Gods Are Angry. The story themes and gameplay are fairly similar, and as a result, I'm taking graphical cues from it as well:

Hopefully this time I don't overscope.