This time I’m going with the tools I’m most comfortable with – browser and javascript.
I can guarantee my game works in Chrome and Firefox but sorry no Safari, Opera, Internet Explorer.
Or maybe I’ll stay Chrome-only and pack the game as standalone app using https://github.com/rogerwang/node-webkit

The libraries I’d like to use are:
https://github.com/Animatron/player – for 2d rendering
https://github.com/jakesgordon/javascript-audio-fx/ – for playing the sounds

I’m not using any specific game framework but quite possibly I’ll take SAT collision detection from crafty.js and A*, RNG from https://github.com/ondras/rot.js