Well, after much deliberation, I’ve finally decided to go with FlatRedBall using C# and VS 2008.

I’ll use this as a basis. It is basically just a screen with a couple of working Sprites with collision detection and some sound effects.
http://www.bitjets.com/asteroids.zip

I’ll use the following tools:

Art drawn with pencil and paper
scanned with Canoscan LiDE 700F
processed, colored and animated with PS5

will probably use Ableton Live and Korg keyboard for music
will try to use foley and voice for sound effects

Let’s see how it goes!